The global in vivo toxicology market in terms of revenue was estimated to be worth $5.0 billion in 2020 and is poised to reach $6.6 billion by 2025, growing at a CAGR of 11.5% from 2020 to 2025. The comprehensive research encompasses an exhaustive examination of industry trends, meticulous pricing analysis, patent scrutiny, insights derived from conferences and webinars, identification of key stakeholders, and a nuanced understanding of market purchasing dynamics.
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In Vivo Toxicology Market Dynamics
Driver: Exclusive in vivo toxicology tests
With the introduction of alternative methods such as in vitro and in silico toxicology testing, several toxicology tests are conducted through laboratory methods. However, certain tests are exclusive to in vivo toxicology testing, such as tests for carcinogenicity, developmental (including teratogenicity in offspring) & reproductive toxicity, mutagenicity, and neurotoxicity.
The growing focus on carcinogenic toxicity tests for drugs is likely to propel the use of animal models for in vivo toxicology testing. According to the Cancer Research Institute, the number of active drugs in development grew by more than 90%, to 3,876 in 2019. Long-term rodent carcinogenicity studies for assessing the carcinogenic potential of drugs in humans are currently being examined.
Restraint: Alternatives to animal testing
Development of improved non-animal In vitro models is expected to restrain the growth of in vivo toxicology market. Such models have gained immense traction in toxicology testing across human stem cells, drugs. cell culture models, and high-throughput testing. Additionally, the increasing adoption of alternative toxicology testing solutions expected to limit the demand for animal models.
Challenge: Regulations and laws for the ethical use of animals in research
Implementing laws and regulations for animal protection and welfare has resulted in restrictive practices and bans on animals for different purposes. In the last five years, many countries have banned the use of animals in the cosmetic industry.
Moreover, institutes funded by the National Institutes of Health (NIH) are required to adhere to Public Health Service (PHS) policy and follow the Guide for the Care and Use of Laboratory Animals developed by the Institute for Laboratory Animal Research (ILAR). To increase the chances of funding, research institutes seek accreditation from the Association for the Assessment and Accreditation of Laboratory Animal Care International (AAALAC), a privately funded membership-based organization.
Opportunity: Rising demand for humanized animal models
Humanized animal models are important tools for conducting preclinical research to gain insights into human biology. These models are developed through the engraftment of human cells or tissues, leading to the expression of human proteins in animals.
Humanized mice are increasingly being used as models for biomedical research applications, such as cancer, infectious diseases, HIV/AIDS, regenerative medicine, and hepatitis. In March 2019, the National Institute of Allergy and Infectious Diseases (NIAID), an agency of the US Department of Health and Human Services, announced funding for projects to conduct detailed characterization, direct comparisons, and further development of humanized immune system (HIS) mouse models. The need to identify the actual effects of drugs on humans, as well as the growing focus on studying human-specific infections, therapies, and immune responses, is promoting the development and use of humanized animal models
By Product, the consumables accounted for the largest share of the in vivo toxicology market
Based on the product, the market is categorized into consumables and instruments Reagents & kits accounted for the largest share of the consumables segment. Wide use of immunoassays for antibody analysis in biological samples is the key attributive factor to the segment growth. Rapid immunoassay (RIA) is an emerging technique that quantifies antigen concentration. Advantages associated with this technique such as, easy automation, high senstitvity, and enhanced signal detection is expected to fuel its adoption in the future.
By toxicity endpoint, the immunotoxicity segment accounted for the largest share of the in vivo toxicology market
Based on toxicity endpoint, the global market is segmented into systemic toxicity, immunotoxicity, genotoxicity, carcinogenicity, developmental & reproductive toxicity (DART), and other toxicity endpoints. Immunotoxicity a result of the adverse effects arising from the immune system functions caused due to excessive drug exposure, biologics, or exposure to chemical compunds. Exposure to benzene, asbestos, and halogenated aromatic hydrocarbons may lead to immunosuppression in humans.
By test type, chronic toxicity testing segment accounted for the largest share of the in vivo toxicology market
Based on test type, the global market is segmented into chronic, sub-chronic, acute, and sub-acute test type. Chronic toxicity tests are carried out with a minimum of one rodent and one non-rodent species. The test compound is administered over more than 90 days, and the animals are observed periodically. A chronic toxicology study provides inferences about the long-term effect of a test substance in animals, and it may be extrapolated to the human safety of the test substance. Hence, drugs used for longer-duration therapy such as chemotherapeutic agents, anti-cancer, anti-convulsive, anti-hypertensives and anti-arthritis require chronic toxicity testing further driving the segment growth.
By testing facility, outsourced testing facilities segment accounted for the largest share of the in vivo toxicology market
Based on the testing facility, the global market is segmented into outsourced testing facilities and in-house testing facilities. The outsourced testing facilities segment accounted for the largest market share in 2020 and is expected to maintain its dominance throughout the forecast period. High focus on cost curtailment and increasing need to access skilled labor boost the segment growth.
By end user, academic and research institutes segment accounted for the largest share of the in vivo toxicology market
Based on the end user, the global market has been broadly segmented into pharmaceutical & biotechnology companies, academic & research institutes, contract research organizations, and other end users. As per an article published in 2019, the number of partnerships amongst academic and corporate institutions has increased significantly from 2016-2019 and this trend is set to continue in the near future. More than 90% of the research papers published by key entities were in collaboration with academic/research institutes and or government labs.
North America accounted for the largest share of the in vivo toxicology market in 2020
North America, includes the US and Canada, accounted for the highest market share in the in vivo toxicology market. High demand for personalized medicines is the key driving factor of the North America market. Additioally, the expansion of the stem cell research sector in Canada, which is primarily driven by large-scale investments due to the implementation of the Canadian Stem Cell Strategy and Action Plan is another contributing factor to the North America market. In 2020, a grant of USD 675,000 to the Stem Cell Network for developinga potential cell therapy against SARS-CoV-2 infection.
Key Market Players
The major players operating in this market are by Charles River Laboratories (US), The Jackson Laboratory (US), Envigo (US), Taconic Biosciences, Inc. (US), and JANVIER LABS (France), Thermo Fisher Scientific (US), Danaher Corporation (US), Waters Corporation (US), Agilent Technologies (US), Shimadzu Corporation (Japan), Bruker Corporation (US), PerkinElmer (US). Other prominent players include Merck KGaA (Germany), GE Healthcare (US), and Bio-Rad Laboratories (US), genOway (France), Cyagen Biosciences (US), GVK BIO (India), PolyGene (Switzerland), Crown Biosciences (US), TransCure bioServices (France), Ozgene Pty Ltd. (Australia), Harbour BioMed (US) among others.
Recent Developments
In 2020, GenOway acquired exclusive worldwide rights from Merck for its foundational CRISPR/Cas9 portfolio in the rodent field.
In 2020, Taconic entered into an agreement with the University of Texas Medical Branch to distribute humanized ACE2 mice for COVID-19 research.
In 2020, The Jackson Laboratory started the production of ACE2 mice to support the research on COVID-19.
In 2020, Danaher Corporation acquired GE Healthcare’s Life Sciences business.
In 2020, Thermo Fisher launched Orbitrap Exploris 240 and Orbitrap Exploris 120 mass spectrometers.
In 2020, Waters Corporation announced the establishment of Immerse Cambridge, a research laboratory in the heart of Cambridge’s Kendall Square. Immerse Cambridge will serve as a strategic, collaborative space in the community, where Waters can partner with academia and research to accelerate the next generation of scientific advancements.
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