The Global In Vivo Toxicology Market size is projected to reach USD 6.6 billion by 2025 from USD 5.0 billion in 2020, at a CAGR of 5.5% during the forecast period. Key attributing factors contributing to the growth of global market include development of innovative animal models and expanding competition in the in vivo toxicology testing market space. However, stringent laws and regulations pertaining to use of animal models in research is expected to emerge as a key challenge to this market.
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In Vivo Toxicology Market Dynamics
Driver: Exclusive in vivo toxicology tests
With the introduction of alternative methods such as in vitro and in silico toxicology testing, several toxicology tests are conducted through laboratory methods. However, certain tests are exclusive to in vivo toxicology testing, such as tests for carcinogenicity, developmental (including teratogenicity in offspring) & reproductive toxicity, mutagenicity, and neurotoxicity.
Restraints: Alternatives to animal testing
Development of improved non-animal In vitro models is expected to restrain the growth of in vivo toxicology market. Such models have gained immense traction in toxicology testing across human stem cells, drugs. cell culture models, and high-throughput testing. Additionally, the increasing adoption of alternative toxicology testing solutions expected to limit the demand for animal models.
Challenge: Regulations and laws for the ethical use of animals in research
Implementing laws and regulations for animal protection and welfare has resulted in restrictive practices and bans on animals for different purposes. In the last five years, many countries have banned the use of animals in the cosmetic industry.
Moreover, institutes funded by the National Institutes of Health (NIH) are required to adhere to Public Health Service (PHS) policy and follow the Guide for the Care and Use of Laboratory Animals developed by the Institute for Laboratory Animal Research (ILAR). To increase the chances of funding, research institutes seek accreditation from the Association for the Assessment and Accreditation of Laboratory Animal Care International (AAALAC), a privately funded membership-based organization.
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Opportunity: Rising demand for humanized animal models
Humanized animal models are important tools for conducting preclinical research to gain insights into human biology. These models are developed through the engraftment of human cells or tissues, leading to the expression of human proteins in animals.
Humanized mice are increasingly being used as models for biomedical research applications, such as cancer, infectious diseases, HIV/AIDS, regenerative medicine, and hepatitis. In March 2019, the National Institute of Allergy and Infectious Diseases (NIAID), an agency of the US Department of Health and Human Services, announced funding for projects to conduct detailed characterization, direct comparisons, and further development of humanized immune system (HIS) mouse models. The need to identify the actual effects of drugs on humans, as well as the growing focus on studying human-specific infections, therapies, and immune responses, is promoting the development and use of humanized animal models
North America accounted for the largest share of the in vivo toxicology market in 2020
North America, includes the US and Canada, accounted for the highest market share in the in vivo toxicology market. High demand for personalized medicines is the key driving factor of the North America market. Additioally, the expansion of the stem cell research sector in Canada, which is primarily driven by large-scale investments due to the implementation of the Canadian Stem Cell Strategy and Action Plan is another contributing factor to the North America market. In 2020, a grant of USD 675,000 to the Stem Cell Network for developinga potential cell therapy against SARS-CoV-2 infection.
Key Market Players
The major players operating in this market are by Charles River Laboratories (US), The Jackson Laboratory (US), Envigo (US), Taconic Biosciences, Inc. (US), and JANVIER LABS (France), Thermo Fisher Scientific (US), Danaher Corporation (US), Waters Corporation (US), Agilent Technologies (US), Shimadzu Corporation (Japan), Bruker Corporation (US), PerkinElmer (US). Other prominent players include Merck KGaA (Germany), GE Healthcare (US), and Bio-Rad Laboratories (US), genOway (France), Cyagen Biosciences (US), GVK BIO (India), PolyGene (Switzerland), Crown Biosciences (US), TransCure bioServices (France), Ozgene Pty Ltd. (Australia), Harbour BioMed (US) among others.
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